Evaluation of myocardial work index in predicting in-hospital complication in patients with Takotsubo syndrome

Abstract Funding Acknowledgements Type of funding sources: None. Backgrounds Tako-tsubo syndrome (TTS) is a reversible heart failure pathology characterized by transient myocardial left ventricular (LV) dysfunction. Although traditionally considered benign condition, in-hospital complications are frequent in this cohort patients. Non-invasive work (MW) parameters as emerging indexes evaluating global and regional systolic function. Aim The aim TTS study was to investigate the potential association MW with complications, compare standard (LVEF) advanced (GLS) echocardiographic LV function Methods thirty-eight patients (mean age, 68 ± 12 years, 35 women) diagnosed Takotsubo Italian Network criteria were prospectively enrolled underwent transthoracic Doppler echocardiography within 24 hours from hospital admission. Clinical characteristics during index event reported table 1. derived non-invasive strain-pressure loop obtained 2D strain data, integrating into its calculation brachial arterial pressure. Constructive (CMW), (MWI), efficiency (MWE), wasted (WMW) measured. GLS EF also In defined composite apical thrombosis, hypokinetic arrhythmias (HA), supraventricular tachycardia (SVT), acute (AHF), tachycardia/fibrillation (VT/VF), cardiogenic shock (CS), respiratory arrest (RA), stroke cardiac death (CD). Results Hospital occurred 16 (26% AHF; 10% SVT; 8% CS; 5% thrombosis; HA; 2,6 % RA; 2,6% stroke; 2% VT/VF). WMW parameter appear have best performance predicting (odds ratio for having HC: 8.4 (95% confidence interval: 1.5 46.1), figure 2). Conclusion transiently impaired significantly associated complication. limited low number patients, these results suggest that may better than value intra-hospital complications. Larger studies will be necessary confirm preliminary results.